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SKU: E-AB-12664_60μL-ES
TOP2A Polyclonal Antibody, 60 μL
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:0.2 mg/mL
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Dilution:IHC 1:50-1:200
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Application:IHC
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Research Areas:Cancer;Epigenetics and Nuclear Signaling
Species Reactivity:Human;Mouse;Rat
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Target Synonym:alpha isozyme;ATP hydrolyzing DNA topoisomerase II alfa;DNA gyrase;DNA topoisomerase (ATP hydrolyzing);DNA topoisomerase 2 alpha;DNA topoisomerase 2-alpha;DNA topoisomerase II 170 kD;DNA topoisomerase II alpha isozyme;DNA topoisomerase II;DNA Topoisomerase2;TOP 2A;TOP2;TOP2A;TOP2A;Topoisomerase DNA II alpha 170kDa;TP2A
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Buffer:PBS with 0.05% sodium azide and 50% glycerol, PH7.4
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Clonality:Polyclonal
Conjugation:Unconjugated
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