- Specification
- Downloads
- Reviews
$165.60
ADD TO CART
SKU: PKSH032420_10μg-ES
Recombinant Human CD16a/FCGR3A Protein (His Tag), 10 μg
Receptors for the Fc region of immunoglobin G (FcγR) are divided into three classes and FcγRIII is a multifunctional; low/intermediate affinity receptor. In humans; FcγRIII is expressed as two distinct forms (FcγRIIIA and FcγRIIIB) that are encoded by two different but highly homologous genes in a cell type-specific manner. FcγRIIIB is a low-affinity; GPI-linked receptor expressed by neutrophils and eosinophils; whereas FcγRIIIA is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed by a subset of T lymphocytes; natural killer (NK) cells; monocytes; and macrophages. The FcγRIIIA receptor is involved in phagocytosis; secretion of enzymes; inflammatory mediators; antibody-dependent cellular cytotoxicity (ADCC); mast cell degranulation; and clearance of immune complexes. FcγRIIIA has an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain and delivers an activation signal in the immune responses. Aberrant expression or mutations in this gene is implicated in susceptibility to recurrent viral infections; systemic lupus erythematosus; and alloimmune neonatal neutropenia. In humans; it is a 50 -70 kD type I transmembrane activating receptor.
- Regular price
- $165.60 USD
- Sale price
- $165.60 USD
- Regular price
-
ADD TO CART
Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
Warranty:
Safety Performance:
Protection Class:
Sterile Status:
Reconstitution:Please refer to the printed manual for detailed information.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Battery:
Battery Service Life:
Component:
Technical Specifications
Capacity:
Concentration:
Dimension [D×W×H]:
Diameter:
Length:
Width:
High:
Volume:
Volume Range:
Speed:
Speed Range:
Max.Speed:
Max. RCF:
Temperature Range:
Operating Temperature Range:
Permissible Ambient Temperature :
Permissible Relative Humidity:
Input voltage:
Power Requirements:
Voltage/Frequency:
Sensitivity:
Specificity:
Precision:
Speed Accuracy:
Volume Accuracy:
Particle Size:
Pore Size:
Binding Capacity:
Calculated Molecular Weight:22.7 kDa
Observed Molecular Weight:35-50 kDa
Purity: > 95 % as determined by reducing SDS-PAGE.
Shelf Life:
Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Random Error:
Acceleration/Braking time:
Aspiration Speed:
Calculated Molecular Weight:22.7 kDa
Dilution:
Driving Motor DC motor:
Em:
Ex:
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Flow rate [liquid]:
Features and Capabilities
Application:
Detection Target:
Detection Type:
Detection Range:
Research Areas:immunology;Stem cells
Species Reactivity:
Reactivity:
Target Synonym:
Test Principle:
Quantitative/Qualitative :
Result Type:
Materials :
Assay Time:
Autoclave component:
Available Rotor Adapters:
Binding Capacity:
Bio-activity:Not validated for activity
Bottom Shape:
Bottom Type:
Buffer:
Cap Color:
Clonality:
Conjugation:
Coupled Ligand:
Cover Type:
Detection Instrument :
Dispensing Speed:
Display:
Form:
Formulation:Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Graduation:
Growth Area: