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SKU: PKSH030348_50μg-ES
Recombinant Human c-Yes/YES1 Protein (His & GST Tag), 50 μg
Proto-oncogene tyrosine-protein kinase Yes, also known as Proto-oncogene c-Yes, p61-Yes and YES1, is a cytoplasm protein which belongs to theprotein kinase superfamily, Tyr protein kinase family and SRC subfamily. YES1 / c-Yes contains oneprotein kinase domain, oneSH2 domain and oneSH3 domain. It is thought that the subcellular distribution of Src-family tyrosine kinases, including c-Yes binding to the cellular membrane, is membranous and/or cytoplasmic. YES1 / c-Yes protein tyrosine kinase is known to be related to malignant transformation. YES1 / c-Yes and c-Src are the two most closely related members of the Src family of nonreceptor tyrosine kinases. Although there is much evidence to support redundancy in signaling between these two kinases. YES1 / c-Yes promotes formation of the tight junction by phosphorylating occludin, while c-Src signaling downregulates occludin formation in a Raf-1 dependent manner. YES1 / c-Yes has tyrosine kinase activity. It promotes infectivity of Neisseria gonorrhoeae in epithelial cells by phosphorylating MCP / CD46.
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Product Specification
Basic Information
Brands:Elabscience
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Place of Origin:China
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Reconstitution:Not Applicable
Shipping:This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
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Calculated Molecular Weight:88.5 kDa
Observed Molecular Weight:75 kDa
Purity: > 80 % as determined by reducing SDS-PAGE.
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Storage:Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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Calculated Molecular Weight:88.5 kDa
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Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
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Application:Enzyme
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Research Areas:Signal Transduction;Neuroscience;Cancer;epigenetics and nuclear signal;
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Bio-activity:The specific activity was determined to be 35 nmol/min/mg using Poly(Glu, Tyr) 4:1 as substrate.
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Formulation:Supplied as sterile solution of 20mM Tris, 500mM NaCl, 10% glycerol, 0.5mM TCEP, pH 8.0
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