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SKU: D-AB-10440L_100μL-ES
MIγ/CXCL9 Polyclonal Antibody, 100 μL
Chemokine (C-X-C motif) ligand 9 (CXCL9),also known as Monokine induced by gamma interferon (MIG),is a small cytokine belonging to the CXC chemokine family. The function of this chemokine has not been specifically defined;however,it is thought to be involved in T cell trafficking. CXCL9/MIG functions as one of the three ligands of chemokine receptor CXCR3 which is a G protein-coupled receptor found predominantly on T cells. CXCL9/MIG,together with CXCL10 and CXCL11,may activate CXCR3 by binding to it. CXCL9 serves as a cytokine that affects the growth,movement,or activation state of cells that participate in immune and inflammatory response. It has been observed that tumour endothelial cells secrete high levels of CXCL9 in all,and CXCL10 in most melanoma metastases. Experiment data represent novel mechanisms by which tumour cells in melanoma metastases might use the chemokine-expressing endothelium to leave the tumour and eventually to form additional metastases at distinct sites. Experiment results also improved that CXCL9/MIG plays an important role in CD4+ T lymphocyte recruitment and development of CAV,MOMA-2+ macrophages are the predominant recipient-derived source of CXCL9/MIG,and recipient CD4 lymphocytes are necessary for sustained CXCL9/MIG production and CAV development in this model. Neutralization of the chemokine CXCL9/MIG may have therapeutic potential for the treatment of chronic rejection after heart transplantation.
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Product Specification
Basic Information
Brands:Elabscience
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Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:1 mg/mL
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Calculated Molecular Weight:14 kDa
Observed Molecular Weight:15 kDa
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:14 kDa
Dilution:WB 1:500-1:1000
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Application:WB
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Research Areas:Epigenetics and Nuclear Signaling;Cancer;CellBiology;Neuroscience;Signal Transduction;Developmental Biology;Immunology
Species Reactivity:Mouse;Rat
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Target Synonym:C-X-C motif chemokine 9;Gamma-interferon-induced monokine;Monokine induced by interferon-gamma (MIG;MuMIG);Protein m119;Small-inducible cytokine B9;Cxcl9;Mig;Scyb9
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Buffer:PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4
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Clonality:Polyclonal
Conjugation:Unconjugated
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