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SKU: AN000150P_100μg-ES
IL-12 p70 Polyclonal Antibody(Capture/Detector), 100 μg
Heterodimerizes with Il12B to form the Il-12 cytokine or with EBI3/Il27B to form the Il-35 cytokine. Il-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses,induces the production of interferon-gamma (IFN-gamma),favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically,exerts its biological effects through a receptor composed of Il12R1 and Il12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn,recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes.As part of Il-35,plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine.Mediates biological events through unconventional receptors composed of Il12RB2 and gp130/Il6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4,which form a unique heterodimer that binds to distinct DNA sites.
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Product Specification
Basic Information
Brands:Elabscience
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Place of Origin:China
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Concentration:1 mg/mL
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Shelf Life:12 months
Storage:Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
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Dilution:ELISA Capture 2-8 μg/mL;ELISA Detector 0.1-0.4 μg/mL
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Application:ELISA Capture/Detector
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Species Reactivity:Rat
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Target Synonym:IL-12A;IL12a;InterLeukin-12 subunit aLpha;Cytotoxic Lymphocyte maturation factor 35 kDa subunit (CLMF p35);IL-12 subunit p35;IL12b;IL12B;InterLeukin-12 subunit beta;Cytotoxic Lymphocyte maturation factor 40 kDa subunit;IL-12 subunit p40
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Buffer:Phosphate buffered solution, pH 7.2, containing 0.05% proclin 300.
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Clonality:Polyclonal
Conjugation:Unconjugated
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