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SKU: E-AB-13295_120μL-ES
HMGCS1 Polyclonal Antibody, 120 μL
HMG-CoA Synthase exists as both a mitochondrial (mHMGCS) and cytoplasmic (cHMGCS) enzyme that condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The HMG-CoA produced by cHMGCS is transformed into mevalonate by HMG-CoA reductase, which starts isoprenoid biosynthesis. End products of the isoprenoid pathway include cholesterol, ubiquinone, dolichol, isopentenyl adenosine and farnesyl groups. mHMGCS, together with HMG-CoA Lyase, is responsible for ketone body biosynthesis. mHMGCS is expressed in liver and kidney. Fasting, cAMP and fatty acids increase the level of transcription of mHMGCS, while feeding and insulin repress it. A regulatory element within the mHMGCS promoter confers transcriptional regulation by PPAR, RXR, COUP-TF and HNF-4.
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:0.4 mg/mL
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Calculated Molecular Weight:57kDa
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:57kDa
Dilution:WB 1:500-1:2000;IHC 1:50-1:200
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Application:WB;IHC
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Research Areas:Cancer;Cardiovascular;Metabolism;Signal Transduction
Species Reactivity:Human
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Target Synonym:3 hydroxy 3 methylglutaryl Coenzyme A synthase 1 (soluble);3-hydroxy-3-methylglutaryl coenzyme A synthase;cytoplasmic;EC 2.3.3.10;HMCS1;HMG CoA synthase;HMG-CoA synthase;HMGCS;HMGCS1;Hydroxymethylglutaryl CoA synthase;cytoplasmic;Hydroxymethylglutaryl-CoA synthase;MGC90332
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Buffer:PBS with 0.05% sodium azide and 50% glycerol, PH7.4
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Clonality:Polyclonal
Conjugation:Unconjugated
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