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SKU: AN000120P_100μg-ES
HMGB-1 Polyclonal Antibody(Capture/Detector), 100 μg
Human High-mobility group box 1 protein (HMGB1),previously known as HMG-1 or amphoterin,is a member of the high mobility group box family of non-histone chromosomal proteins.HMGB1 is expressed at high levels in almost all cells. It was originally discovered as a nuclear protein that could bend DNA. Such bending stabilizes nucleosome formation and regulates the expression of select genes upon recruitment by DNA binding proteins. It is now known that HMGB1 can also act extracellularly,both as an inflammatory mediator that promotes monocyte migration and cytokine secretion,and as a mediator of T cell-dendritic cell interaction. The cytokine activity of HBMG1 is restricted to the HMG B box,while the A box is associated with the helix-loop-helix domain of transcription factors. HMBG1 is released in response to cell death and as a secretion product. Although HMBG-1 does not possess a classic signal sequence,it appears to be secreted as an acetylated form via secretory endolysosome exocytosis. Once secreted,HMGB1 transduces cellular signals through its high affinity receptor,RAGE and,possibly,TlR2 and TlR4. Human HMGB1 is 100% aa identical to canine HMGB1 and 99% aa identical to mouse,rat,bovine and porcine HMGB1,respectively.
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Product Specification
Basic Information
Brands:Elabscience
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Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:1 mg/mL
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Calculated Molecular Weight:29kDa
Observed Molecular Weight:29kDa
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Shelf Life:12 months
Storage:Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
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Calculated Molecular Weight:29kDa
Dilution:WB 1:500-1:1000;ELISA Capture 2-8 μg/mL;ELISA Detector 0.1-0.4 μg/mL
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Application:WB;ELISA Capture/Detector
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Research Areas:Epigenetics and Nuclear Signaling
Species Reactivity:Human;Mouse;Rat
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Target Synonym:HMGB1;HMG1;High mobiLity group protein B1;High mobiLity group protein 1 (HMG-1)
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Buffer:Phosphate buffered solution, pH 7.2, containing 0.05% proclin 300.
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Clonality:Polyclonal
Conjugation:Unconjugated
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