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SKU: E-AB-12364_60μL-ES
DDB1 Polyclonal Antibody, 60 μL
The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:0.3 mg/mL
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Calculated Molecular Weight:127kDa
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:127kDa
Dilution:WB 1:200-1:500
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Application:WB
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Research Areas:Cancer;Epigenetics and Nuclear Signaling
Species Reactivity:Human;Mouse;Rat
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Target Synonym:Damage specific DNA binding protein 1;Damage-specific DNA-binding protein 1;DDB 1;DDB p127 subunit;Ddb1;DDB1;DDBa;DNA damage binding protein 1;DNA damage-binding protein 1;DNA damage-binding protein a;HBV X-associated protein 1;UV damaged DNA binding factor;UV damaged DNA binding protein 1;UV DDB 1;UV DDB1;UV-damaged DNA-binding factor;UV-damaged DNA-binding protein 1;UV-DDB 1;X associated protein 1;XAP 1;XAP-1;XAP1;Xeroderma pigmentosum group E complementing protein;Xeroderma pigmentosum group E-complementing protein;XPCe;XPE;XPE BF;XPE binding factor;XPE-BF;XPE-binding factor
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Buffer:PBS with 0.05% sodium azide and 50% glycerol, PH7.4
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Clonality:Polyclonal
Conjugation:Unconjugated
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