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SKU: AN000440P_25μg-ES
Cortisol Binding Globulin/CBG/SERPINA6 Polyclonal Antibody(Capture/Detector), 25 μg
Corticosteroid-binding globulin (CBG),also known as SerpinA6,is a non-inhibitory member of the serine proteinase inhibitor (serpin) superfamily. It is the high-affinity transport protein for glucocorticoids in vertebrate blood. CBG is specifically cleaved by this protease at a precise site close to its carboxy-terminus. This induces a conformation change and disrupts the binding between glucocorticoids and CBG,and promotes a significant and local release of glucocorticoids (over 90% of them are bound to CBG in human plasma). In this context,CBG directs glucocorticoids to sites of inflammation,and plays in consequence a crucial role in efficient glucocorticoid action in physiology. The SerpinA6 protein is mainly secreted by the liver. This negative acute phase protein regulates free cortisol levels in the blood and distributes cortisol to its target tissues. SerpinA6 deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration,and normal or low basal cortisol levels associated with hypo-/hypertension and muscle fatigue. There are three heritable,human CBG gene mutations that can reduce CBG-cortisol binding affinity and/or reduce circulating CBG levels.
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:1 mg/mL
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Calculated Molecular Weight:45kDa
Observed Molecular Weight:60kDa
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Shelf Life:12 months
Storage:Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
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Calculated Molecular Weight:45kDa
Dilution:WB 1:500-1:1000;IF 1:50-1:200;ELISA Capture 2-8 μg/mL;ELISA Detector 0.1-0.4 μg/mL
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Application:WB;IF;ELISA Capture/Detector
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Research Areas:Signal Transduction;Metabolism
Species Reactivity:Human;Mouse
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Target Synonym:Corticosteroid-binding gLobuLin;CBG;Serpin A6;Transcortin;SERPINA6;CBG
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Buffer:Phosphate buffered solution, pH 7.2, containing 0.05% proclin 300.
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Clonality:Polyclonal
Conjugation:Unconjugated
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