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SKU: D-AB-10383L_25μL-ES
CDNF Polyclonal Antibody, 25 μL
Cerebral Dopamine Neurotrophic Factor (CDNF),also known as ARMETL1 (ARMET-like protein 1),is a secreted protein with eight conserved cysteine residues,predicting a unique protein fold and defining a new,evolutionarily conserved protein family. CDNF is a novel neurotrophic factor with strong trophic activity on dopaminergic neurons comparable to that of glial cell line-derived neurotrophic factor (GDNF). CDNF/ARMETL1 is a evolutionary conserved protein which can protect and restore the function of dopaminergic neurons in the rat model of Parkinson's disease,suggesting that CDNF might be beneficial for the treatment of Parkinson's disease. CDNF is widely expressed in neurons in several brain regions including cerebral cortex,hippocampus,substantia nigra,striatum and cerebellum. Human CDNF is glycosylated and secreted from transiently transfected cells. CDNF promotes the survival,growth,and function of dopamine-specific neurons and is expressed in brain regions that undergo cocaine-induced neuroplasticity.
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:1 mg/mL
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Calculated Molecular Weight:21kDa
Observed Molecular Weight:17kDa
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:21kDa
Dilution:WB 1:500-1:1000
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Application:WB
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Research Areas:Neuroscience
Species Reactivity:Rat
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Target Synonym:Cerebral dopamine neurotrophic factor;ARMET-like protein 1;Conserved dopamine neurotrophic factor;CDNF;ARMETL1
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Buffer:PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4
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Clonality:Polyclonal
Conjugation:Unconjugated
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