SKU: AN004630P_25μg-ES

CCL18/PARC Polyclonal Antibody(Capture/Detector), 25 μg

CCL18, also known as alternative macrophage activation-associated CC chemokine (AMAC)-1, macrophage inflammatory protein (MIP)-4, and dendritic cell chemokine (DC-CK1), is a novel CC chemokine that is highly homologous to MIP-1 alpha (61% amino acid (aa) sequence identity). CCL18 cDNA encodes an 89 aa residue precursor protein with a 20 aa putative signal peptide that is cleaved to generate a 69 aa residue mature protein which lacks potential glycosylation sites. In vitro, CCL18 mRNA expression is induced in alternatively activated macrophages by Th2 cytokines such as IL-4, IL-10, and IL-13, and inhibited by IFN‑ gamma. CCL18 mRNA is also expressed by GM-CSF/IL-4-induced monocyte-derived dendritic cells. In vivo, CCL18 is highly expressed in lung and placenta but is not expressed in epidermal Langerhans cells. Recombinant CCL18 has been shown to chemoattract naive T cells but not monocytes or neutrophils.

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Product Specification

Basic Information

Brands:Elabscience

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Place of Origin:China

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Shipping:The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

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Concentration:1 mg/mL

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Shelf Life:12 months

Storage:Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

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Dilution:ELISA Capture 2-8 μg/mL;ELISA Detector 0.1-0.4 μg/mL

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Application:ELISA Capture/Detector

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Research Areas:Immunology

Species Reactivity:Human

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Target Synonym:CKb;TSC;DCCK;DC-CK;Eotaxin;AMAC-1;CCL26;CKb7;DC-CK1;Eotaxin-3;IMAC;MIP-4;MIP-4a;SCYA26;TSC-1;AMAC1;MIP4;PARC;SCYA18;CCL18;AMAC-1;CKb7;DCCK1;DC-CK1;MIP-4;Alternative macrophage activation associated CC chemokine 1;Alternative macrophage activation-associated CC chemokine 1;CC chemokine PARC;C-C Motif Chemokine 18;CCL18(4-69);Dendritic cell chemokine 1;Macrophage inflammatory protein 4;Pulmonary and activation regulated chemokine;Pulmonary and activation-regulated chemokine;Small inducible cytokine A18;Small-inducible cytokine A18

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Buffer:Phosphate buffered solution, pH 7.2, containing 0.05% proclin 300.

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Clonality:Polyclonal

Conjugation:Unconjugated

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