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SKU: E-AB-64459_120μL-ES
CASC5 Polyclonal Antibody, 120 μL
The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11;15)(q23;q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed.
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:1mg/mL
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Calculated Molecular Weight:195kDa/205kDa/262kDa/265kDa
Observed Molecular Weight:300kDa
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:195kDa/205kDa/262kDa/265kDa
Dilution:WB 1:500-1:2000;IHC 1:50-1:100
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Application:WB;IHC
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Research Areas:Cell Biology;Cancer;Stem Cells
Species Reactivity:Human;Rat
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Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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Clonality:Polyclonal
Conjugation:Unconjugated
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