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SKU: E-AB-15460_20μL-ES
ADO Polyclonal Antibody, 20 μL
Human thiol dioxygenases include cysteine dioxygenase (CDO, MIM 603943) and cysteamine (2-aminoethanethiol) dioxygenase (ADO, EC 1.13.11.19). CDO adds 2 oxygen atoms to free cysteine, whereas ADO adds 2 oxygen atoms to free cysteamine to form hypotaurine. Mouse Ado has strong and specific dioxygenase activity in vitro towards cysteamine but not cysteine. Recombinant Ado was shown to bind iron. Overexpression of Ado in HepG2/C3A cells increased the production of hypotaurine from cysteamine. Similar results were found with human ADO. When endogenous expression of ADO was reduced by RNA-mediated interference, hypotaurine production decreased. The demonstration of high levels of ADO in brain challenges the previous assumption that most of the taurine in the brain is a consequence of CDO activity.
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:0.3 mg/mL
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Calculated Molecular Weight:30kDa
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:30kDa
Dilution:WB 1:1000-1:5000;IHC 1:25-1:100
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Application:WB;IHC
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Research Areas:Metabolism;Signal Transduction
Species Reactivity:Human;Mouse
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Target Synonym:2 aminoethanethiol dioxygenase;2-aminoethanethiol dioxygenase;ADO 2 aminoethanethiol (cysteamine) dioxygenase;ADO;AEDO;C10orf22;Chromosome 10 open reasing frame 22;cysteamine (2-aminoethanethiol) dioxygenase (ADO);Cysteamine dioxygenase;DKFZp564C046;FLJ14547
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Buffer:PBS with 0.05% sodium azide and 50% glycerol, PH7.4
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Clonality:Polyclonal
Conjugation:Unconjugated
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