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SKU: D-AB-10442L_25μL-ES
ACTα2 Polyclonal Antibody, 25 μL
alpha-2-macroglobulin,also known as α2-macroglobulin(α2M and A2M),is an abundant protein of the plasma of vertebrates and members of several invertebrate phyla and functions as a broad-spectrum protease-binding protein. alpha-2-macroglobulin is produced by the liver,and is a major component of the alpha-2 band in protein electrophoresis. alpha-2-macroglobulin is a large plasma glycoprotein that has long been known as an irreversible inhibitor of a variety of proteinases. More recently,it has been reported that numerous growth factors,cytokines and hormones bind to alpha 2M through diverse mechanisms. A2M is also produced in the brain where it binds multiple extracellular ligands and is internalized by neurons and astrocytes. In the brain of Alzheimer's disease (AD) patients,A2M has been localized to diffuse amyloid plaques. A2M also binds soluble beta-amyloid,of which it mediates degradation. Protease-conjugated alpha2-macroglobulin is selectively bound by cells contacting the body fluids and alpha2-macroglobulin and its protease cargo are then internalized and degraded in secondary lysosomes of those cells. In addition to this function as an agent for protease clearance,alpha2-macroglobulin binds a variety of other ligands,including several peptide growth factors and modulates the activity of a lectin-dependent cytolytic pathway in arthropods.
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Product Specification
Basic Information
Brands:Elabscience
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Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:1 mg/mL
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Calculated Molecular Weight:42 kDa
Observed Molecular Weight:42 kDa
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:42 kDa
Dilution:WB 1:500-1:1000
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Application:WB
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Research Areas:Immunology;Neuroscience;Stem Cells
Species Reactivity:Human
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Target Synonym:Actin;aortic smooth muscle;Alpha-actin-2;Actin;aortic smooth muscle;intermediate form;Acta2;Actsa;Actvs
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Buffer:PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4
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Clonality:Polyclonal
Conjugation:Unconjugated
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