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SKU: E-AB-10119_60μL-ES
ABL1 Polyclonal Antibody, 60 μL
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.
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Product Specification
Basic Information
Brands:Elabscience
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Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:0.5 mg/mL
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Dilution:IHC 1:50-1:200
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Application:IHC
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Research Areas:Cancer;Epigenetics and Nuclear Signaling;Signal Transduction
Species Reactivity:Human;Mouse
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Target Synonym:Abelson murine leukemia viral oncogene homolog 1;Abelson tyrosine protein kinase 1;Abl 1;ABL;ABL proto oncogene 1 non receptor tyrosine kinase;ABL1;ABL1;bcr/abl;bcr/c abl oncogene protein;c ABL;c abl oncogene 1 non receptor tyrosine kinase;c abl oncogene 1 receptor tyrosine kinase;c ABL1;JTK7;p150;Proto oncogene tyrosine protein kinase ABL1;Proto-oncogene c-Abl;Tyrosine-protein kinase ABL1;v abl Abelson murine leukemia viral oncogene homolog 1;v abl
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Buffer:PBS with 0.05% sodium azide and 50% glycerol, PH7.4
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Clonality:Polyclonal
Conjugation:Unconjugated
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