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Código SKU: E-AB-22169_20μL-ES
Anticuerpo monoclonal TBP, 20 μL
Este gen codifica la TBP, la proteína de unión a TATA. Una característica distintiva de la TBP es una larga cadena de glutaminas en el extremo N-terminal. Esta región de la proteína modula la actividad de unión al ADN del extremo C-terminal, y la modulación de dicha unión afecta la velocidad de formación del complejo de transcripción y el inicio de la transcripción. El número de repeticiones CAG que codifican el tracto de poliglutamina suele ser de 32 a 39, y la expansión del número de repeticiones aumenta la longitud de la cadena de poliglutamina y se asocia con la ataxia espinocerebelosa tipo 17, un trastorno neurodegenerativo clasificado como enfermedad por poliglutamina.
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