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Código SKU: E-AB-53335_200μL-ES
Anticuerpo policlonal STARD4, 200 μL
La homeostasis del colesterol está regulada, al menos en parte, por las proteínas de unión al elemento regulador de esteroles (SRE) (p. ej., SREBP1; MIM 184756) y por los receptores X del hígado (p. ej., LXRA; MIM 602423). Tras el agotamiento de esteroles, los LXR se inactivan y los SREBP se escinden, tras lo cual se unen a los SRE promotores y activan genes implicados en la biosíntesis y la captación del colesterol. El transporte de esteroles está mediado por vesículas o por transportadores proteicos solubles, como la proteína reguladora aguda esteroidogénica (STAR; MIM 600617). STAR es homóloga a una familia de proteínas que contienen un dominio de transferencia de lípidos relacionado con STAR (START) de 200 a 210 aminoácidos, incluyendo STARD4 (Soccio et al., 2002 [PubMed 12011452]).
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