Código SKU: PKSR030166_100μg-ES

Proteína recombinante COL4A3 de rata (etiqueta Fc), 100 μg

COL4A3 es un componente estructural importante de las membranas basales. Está compuesto por tres subunidades alfa, codificadas por seis genes diferentes, del alfa 1 al alfa 6. Cada una de estas subunidades alfa puede formar una estructura de triple hélice con otras dos subunidades para formar COL4A3. La unión de autoanticuerpos a las moléculas de colágeno en las membranas basales de los alvéolos y glomérulos puede causar el síndrome de Goodpasture. COL4A3 también está vinculado a una forma autosómica recesiva del síndrome de Alport. COL4A3 presenta una conformación cabeza a cabeza y cada par de genes comparte un promotor común.

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