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Código SKU: PKSR030136_50μg-ES
Proteína recombinante de rata B7-H6/NCR3LG1 (ECD, etiqueta Fc), 50 μg
El ligando 1 del receptor 3 desencadenante de citotoxicidad natural (B7-H6) es un miembro glicosilado de la familia B7 de proteínas inmunoestimulantes. El B7-H6 humano maduro consta de un dominio extracelular (ECD) de 238 aminoácidos (aa) que contiene un dominio V similar a Ig y un dominio C1 similar a Ig, un segmento transmembrana de 21 aa y un dominio citoplasmático de 171 aa que contiene un motivo ITIM, uno SH2 y uno SH3. Ambos dominios similares a Ig presentan glucosilación ligada a N. El dominio V similar a Ig media la unión estequiométrica 1:1 de B7-H6 a NKp30 expresado en células NK. No muestra unión a NKp44, NKp46 ni NKG2D. La ligación de NKp30 por B7-H6 induce la activación de las células NK y la citólisis de las células diana. B7-H6 se expresa en una amplia gama de células tumorales hematopoyéticas, carcinomatosas y de melanoma, lo que es consistente con la detección de sitios de unión de NKp30 en muchos tumores.
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