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Código SKU: PKSM041101_50μg-ES
Proteína recombinante CD300a/LMIR1 de ratón (etiqueta Fc), 50 μg
LMIR1, también denominada CD300a, es una glucoproteína transmembrana de tipo I con un único dominio extracelular similar a IgV y una región proximal a la membrana extendida que une los dominios de inmunoglobulina (Ig) y transmembrana, y pertenece a la superfamilia de las inmunoglobulinas. El dominio intracelular de LMIR1 contiene varios motivos de inhibición inmunorreceptores basados en tirosina (ITIM). Al entrecruzarse, se fosforila en tirosina y es capaz de reclutar tirosina fosfatasas (SHP-1, SHP-2) e inositol polifosfato 5-fosfatasa (SHIP). LMIR1 regula las respuestas inflamatorias mediadas por mastocitos. LMIR1 se expresa ampliamente en células mieloides y linfoides, y su expresión se regula de forma diferencial según el tipo celular.
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Brands:Elabscience
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