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Código SKU: PKSM040763_200μg-ES
Proteína AgRP/AGRP recombinante de ratón (etiqueta Fc), 200 μg
La proteína relacionada con agutí (AGRP o AGRT) es un antagonista endógeno de los receptores de melanocortina MC3R y MC4R, presentes en el hipotálamo, y exhibe una potente actividad orexigénica. La AGRP puede actuar como antagonista competitivo de los péptidos derivados de la proopiomelanocortina (POMC) en el receptor de melanocortina-4 (MC4R), y este mecanismo homeostático es importante para coordinar el apetito con la necesidad metabólica percibida. La AGRP se regula positivamente con el ayuno, mientras que las inyecciones intracerebroventriculares de AGRP sintética inducen un aumento del apetito y la ingesta de alimentos. Por lo tanto, la AGRP es un potente péptido orexigénico que aumenta la ingesta de alimentos cuando se sobreexpresa de forma ubicua o se administra por vía central.
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