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Código SKU: PDEH100910_100μg-ES
Proteína TRAPPC8 humana recombinante (etiqueta His), 100 μg
El complejo de partículas proteicas transportadoras (TRAPP) se identificó inicialmente como un factor de anclaje para la vesícula COPII. Posteriormente, se encontraron tres formas (TRAPPI, II y III), y se ha descrito que TRAPPIII actúa como regulador de la autofagia. Este estudio investiga una nueva función de TRAPPIII en mamíferos en la ciliogénesis. Se encontró una proteína de ciliopatía, el síndrome orofacial-digital 1 (OFD1), que interactúa con las subunidades específicas de TRAPPIII, TRAPPC8 y TRAPPC12. TRAPPC8 es necesaria para la asociación de OFD1 con el material pericentriolar 1 (PCM1).
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