Código SKU: PKSH032367_50μg-ES

Proteína STUB1 humana recombinante, 50 μg

La E3 Ubiquitina-Proteína Ligasa CHIP es una proteína citoplasmática. CHIP se expresa ampliamente en músculo esquelético, corazón, páncreas, cerebro y placenta. CHIP interactúa con las chaperonas moleculares Hsc70-Hsp70 y Hsp90 a través de su dominio TPR, lo que provoca la ubiquitinación y degradación del sustrato en el cliente por el proteasoma. CHIP dirige los sustratos de chaperonas mal plegadas hacia la degradación proteasomal. CHIP media la transferencia de cadenas cortas de ubiquitina no canónicas a HSPA8, que no tienen efecto en la degradación de HSPA8. CHIP participa en la reparación por escisión de bases: cataliza la poliubiquitinación amplificando la monoubiquitinación dependiente de HUWE1/ARF-BP1 y provocando la degradación de POLB por el proteasoma. También puede regular la estabilidad y la actividad del receptor mediante la degradación proteasomal.

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