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Código SKU: PKSH033291_10μg-ES
Proteína SMPDL3A humana recombinante (etiqueta His), 10 μg
La fosfodiesterasa 3a similar a la esfingomielinasa ácida (SMPDL3A) es un nuevo gen regulado por el receptor X hepático (LXR); su promotor incluye un elemento de respuesta a LXR. La inducción de SMPDL3A depende de LXR y se limita a las células sanguíneas humanas, sin que se haya observado inducción en sistemas celulares murinos. Los LXR funcionan como sensores fisiológicos de los metabolitos del colesterol (oxiesteroles), regulando genes clave implicados en el metabolismo del colesterol y los lípidos. Los LXR se han estudiado ampliamente en sistemas celulares humanos y de roedores, lo que revela su potencial valor terapéutico en el contexto de la aterosclerosis y las enfermedades inflamatorias.
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