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Código SKU: PKSH033027_10μg-ES
Proteína humana recombinante SENP7, 10 μg
La proteasa específica de sentrina 7 (SENP7) actúa como una proteasa específica de SUMO-2/3. Es probable que SENP7 regule el metabolismo de poli-SUMO-2/3 en lugar de la conjugación de SUMO-1 in vivo. SENP7 tiene una especificidad de sustrato restringida y muestra actividad isopeptidasa específica para el parálogo. El dominio catalítico C-terminal de SENP7 despolimeriza cadenas de poli-SUMO-2, pero no presenta actividad contra cadenas de poli-SUMO-1. SENP7 también mostró actividad isopeptidasa contra RanGAP1 (proteína activadora de la GTPasa de Ran) modificada por di-SUMO-2 y SUMO-2, pero mostró una actividad limitada contra RanGAP1 modificada por SUMO-1.
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