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Código SKU: PDMH100124_20μg-ES
Proteína esclerostina/SOST humana recombinante (etiqueta His), 20 μg
La esclerostina, también conocida como SOST, pertenece a la familia Cerberus/DAN de antagonistas de las BMP. SOST es una glucoproteína secretada con un dominio tipo nudo de cisteína (CTCK) en el extremo C-terminal. Presenta similitud de secuencia con la familia DAN (genes aberrativos seleccionados por cribado diferencial en neuroblastoma) de antagonistas de las proteínas morfogenéticas óseas (BMP). SOST es producida por el osteocito y tiene efectos antianabólicos sobre la formación ósea. Es un regulador negativo del crecimiento óseo que actúa inhibiendo la señalización de Wnt y la formación ósea.
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