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Código SKU: PKSH032974_50μg-ES
Proteína recombinante humana proteinasa 3/PRTN3 (etiqueta His), 50 μg
La proteinasa-3 es una serina proteinasa neutra que pertenece a la familia de las peptidasas S1 y a la subfamilia de las elastasas. Contiene un dominio de peptidasa S1 y se expresa principalmente en los granulocitos neutrófilos. Se cree que su función principal es la degradación de proteínas extracelulares en los focos de inflamación, pero una actividad proteolítica excesiva o prolongada puede causar efectos nocivos en el organismo. Es el epítopo de los anticuerpos anticitoplasma de neutrófilos (ANCA) del subtipo cANCA (citoplasmático), un tipo de anticuerpo que se encuentra frecuentemente en la granulomatosis de Wegener.
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