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Código SKU: PDEH100895_20μg-ES
Proteína NEDD8 humana recombinante (etiqueta His), 20 μg
La NEDD8 humana comparte un 60% de identidad de secuencia de aminoácidos con la ubiquitina. Los únicos sustratos conocidos de la modificación de NEDD8 son las subunidades culinas de las ligasas E3 de ubiquitina SCF. La NEDDilación de las culinas es crucial para el reclutamiento de E2 al complejo de la ligasa, facilitando así la conjugación con la ubiquitina. Por lo tanto, la modificación de NEDD8 se ha implicado en la progresión del ciclo celular y la regulación del citoesqueleto.
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