Código SKU: PKSH033582_50μg-ES

Proteína NACHRA5/CHRNA5 humana recombinante (etiqueta His), 50 μg

La subunidad α-5 del receptor neuronal de acetilcolina (NACHRA5) pertenece a la familia de canales iónicos regulados por ligando. El AChR neuronal se compone de dos tipos diferentes de subunidades: α y no α. Cuando NACHRA5 se une a la acetilcolina, el AChR responde con un cambio de conformación extenso que afecta a todas las subunidades, lo que provoca la apertura de un canal conductor de iones a través de la membrana plasmática. Las variaciones genéticas en NACHRA5 se han relacionado con la susceptibilidad a rasgos de comportamiento relacionados con el tabaquismo y el cáncer de pulmón, lo que contribuye al locus 3 del rasgo cuantitativo del tabaquismo.

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