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Código SKU: PKSH033435_50μg-ES
Proteína LDLR humana recombinante (etiqueta His), 50 μg
El receptor de lipoproteínas de baja densidad (LDLR) es una glucoproteína transmembrana que desempeña un papel fundamental en la homeostasis del colesterol. El LDLR media el nivel de colesterol sanguíneo al interactuar con partículas lipoproteicas como las LDL y las VLDL. El dominio extracelular del LDLR contiene módulos del receptor de LDL tipo A (repeticiones LA), módulos similares al factor de crecimiento epidérmico y repeticiones LY que contienen el motivo consenso YWTD, importantes para la unión y liberación de ApoB-100 y ApoE en las partículas lipoproteicas. El dominio C-terminal del LDLR dentro de la célula es necesario para la internalización del receptor. Las mutaciones con pérdida de función en el gen LDLR causan hipercolesterolemia familiar (HF).
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