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Código SKU: PKSH032666_50μg-ES
Proteína calicreína humana recombinante 2/KLK2 (etiqueta His), 50 μg
La calicreína-2 (KLK2) es una serina proteasa secretada que pertenece a la familia de las peptidasas S1 de la subfamilia de las calicreínas. KLK2 contiene un dominio de peptidasa S1. Se expresa ampliamente en la próstata humana. KLK2 puede escindir los enlaces Met-Lys y Arg-Ser en el quininógeno para liberar lis-bradicinina, pero escinde preferentemente los enlaces Arg-|-Xaa en sustratos de moléculas pequeñas. Su acción altamente selectiva para liberar calidina (lisil-bradicinina) del quininógeno implica la hidrólisis de Met-|-Xaa o Leu-|-Xaa. KLK2 es inhibida por serpinas como el inhibidor de la proteína C, la antiquimotripsina y el plasminógeno. KLK2 se considera un biomarcador del cáncer de próstata.
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