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Código SKU: PKSH033404_10μg-ES
Proteína calicreína humana recombinante 11/KLK11 (etiqueta His), 10 μg
La calicreína humana 11 (KLK11) pertenece a la familia de las calicreínas tisulares, compuestas por serina proteasas extracelulares de 15 miembros. Dos isoformas de KLK11 se expresan diferencialmente. La isoforma 1 se expresa predominantemente en el cerebro y la isoforma 2 se expresa preferentemente en la próstata. La isoforma 1 consta de un péptido señal, un propéptido corto y la cadena madura. La isoforma 2 contiene 32 aminoácidos adicionales en el extremo N-terminal de la isoforma 1 completa. KLK11 es un nuevo marcador para carcinomas de ovario y próstata. KLK11 puede ser activado por termolisina y es activo contra un sustrato de tioéster.
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