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Código SKU: PKSH032642_20μg-ES
Proteína interleucina-33/IL-33 humana recombinante (etiqueta His), 20 μg
La interleucina-33 (IL-33) pertenece a la superfamilia IL-1. La IL-33 se expresa en gran medida en las vénulas endoteliales de las amígdalas, las placas de Peyer y los ganglios linfáticos mesentéricos, pero es prácticamente indetectable en la placenta. La IL-33 induce la producción de citocinas asociadas a los linfocitos T cooperadores-2 (Th2). La IL-33 es una citocina que media sus efectos biológicos uniéndose a IL1RL1/ST2 y a la proteína accesoria del receptor de IL-1 (IL1RAP) y señalizándolas a través de ellas; activando moléculas intracelulares en las vías de señalización de las quinasas NF-κB y MAP, que impulsan la producción de citocinas de tipo 2 a partir de células Th2 polarizadas.
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