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Código SKU: PKSH034137_20μg-ES
Proteína BMP-10 humana recombinante (His Tag), 20 μg
Necesario para mantener la actividad proliferativa de los cardiomiocitos embrionarios, previniendo la activación prematura del regulador negativo del ciclo celular CDKN1C/p57KIP y manteniendo los niveles de expresión necesarios de factores cardiogénicos como MEF2C y NKX2-5. Actúa como ligando para ACVRL1/ALK1, BMPR1A/ALK3 y BMPR1B/ALK6, lo que induce la activación de los factores de transcripción SMAD1, SMAD5 y SMAD8. Inhibe la migración y el crecimiento de células endoteliales. Puede reducir la migración celular y la adhesión a la matriz celular en líneas celulares de cáncer de mama.
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