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Código SKU: PKSH033559_50μg-ES
Proteína BDNF humana recombinante (con propéptido), 50 μg
La forma precursora del factor neurotrófico derivado del cerebro (pro-BDNF) interactúa preferentemente con el receptor de panneurotrofina p75 (p75NTR) y el receptor sortilina, que contiene el dominio vps10p, e induce la apoptosis neuronal. Por otro lado, el BDNF maduro se une selectivamente con alta afinidad al receptor de la quinasa TrkB y promueve la supervivencia, el crecimiento y la diferenciación neuronal. Dado que las proneurotrofinas y las neurotrofinas maduras producen efectos biológicos opuestos, la escisión del pro-BDNF en el sistema neuronal se regula de forma específica y dependiente del contexto celular. El pro-BDNF desempeña un papel importante en la regulación negativa de las acciones neurotróficas en el cerebro.
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