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Código SKU: PDEH100967_20μg-ES
Proteína humana recombinante ATXN7L1 (etiqueta His), 20 μg
ATXN7 se encuentra en el citoplasma de todas las poblaciones neuronales analizadas en cerebros de control, pero se observa marcaje nuclear en algunas neuronas con una frecuencia e intensidad poco correlacionadas con la topografía de las lesiones en los pacientes. La ataxina-7 es un componente del complejo que contiene TAF libre de la proteína de unión a Tata (TBP) (TFTC) y del complejo de acetiltransferasa SPT3/TAF9/GCN5 (STAGA), que participa en varios pasos de la regulación transcripcional, como la acetilación/desubiquitinilación de histonas y el reclutamiento del complejo de preiniciación a los promotores.
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