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Código SKU: PDMH100054_100μg-ES
Proteína apolipoproteína(a)/Lp(a) humana recombinante (etiqueta His), 100 μg
La apo(a) es el componente principal de la lipoproteína(a) (Lp(a)). Posee actividad de serina proteinasa y es capaz de autoproteólisis. Inhibe el activador tisular del plasminógeno tipo 1. La Lp(a) puede ser un ligando para la megalina/Gp 330. Se sabe que la apo(a) se escinde proteolíticamente, lo que conduce a la formación de la denominada mini-Lp(a). Los fragmentos de apo(a) se acumulan en lesiones ateroscleróticas, donde pueden promover la trombogénesis. La O-glicosilación puede limitar el grado de fragmentación proteolítica. Se cree que la homología con los kringles IV y V del plasminógeno subyace a la aterogenicidad de la proteína, ya que los fragmentos compiten con el plasminógeno por la unión a la fibrina(o).
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