Código SKU: PKSH032064_10μg-ES

Proteína APBA3 humana recombinante (etiqueta His), 10 μg

El miembro 3 de la familia A de la proteína precursora de unión al amiloide β A4 (APBA3) es una proteína adaptadora perteneciente a la familia X11. APBA3 contiene dos dominios PDZ (DHR) y un dominio PID, e interactúa con la proteína precursora amiloide de la enfermedad de Alzheimer. Se cree que APBA3 participa en los procesos de transducción de señales. A diferencia de X11-α y -β, que generalmente son proteínas neuronales, APBA3 se expresa ampliamente en todos los tejidos examinados, con niveles más bajos en el cerebro y los testículos. Se une al dominio citoplasmático de la proteína amiloide (APP) in vivo y puede modular el procesamiento de la proteína precursora β-amiloide (APP) y, por consiguiente, la formación de β-APP.

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