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Código SKU: E-AB-53174_120μL-ES
Anticuerpo policlonal RBM4, 120 μL
RBM4, proteína 4 con motivo de unión al ARN, contiene dos motivos de unión al ARN de tipo RRM y un dedo de zinc de tipo retroviral (RT). Este factor de unión al ARN participa en diversos aspectos de los procesos celulares, como el empalme alternativo del pre-ARNm y la regulación de la traducción. RBM4 recluta a eIF4A1 para estimular la traducción dependiente de IRES en respuesta al estrés celular. Una vez ensamblado en el rHRE, el complejo HIF2A-RBM4-eIF4E2 captura la tapa 5-prime y dirige los ARNm a los polisomas para la traducción activa, evadiendo así la represión de la síntesis de proteínas inducida por la hipoxia.
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