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Código SKU: E-AB-F1052F_100T-ES
Anticuerpo anti-CD45RA humano PerCP [HI100], 100 T
El CD45RA es una glucoproteína monocatenaria de tipo I de 205-220 kD. Es una variante de empalme del exón 4 de la tirosina fosfatasa CD45. La isoforma CD45RA se expresa en linfocitos T en reposo/vírgenes, timocitos medulares, linfocitos B y monocitos. El CD45RA potencia la señalización de los receptores de linfocitos T y B. El CD45 se asocia de forma no covalente con la fosfoproteína asociada a la fosfatasa linfocítica (LPAP) en los linfocitos T y B. Se ha descrito que el CD45 se asocia con otros antígenos de superficie celular, como CD1, CD2, CD3 y CD4. También se ha descrito que el CD45 se une a la galectina-1. La expresión de la isoforma CD45 puede variar en respuesta a las citocinas.
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