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Código SKU: E-AB-93132_120μL-ES
Anticuerpo policlonal DNMT1, 120 μL
Este gen codifica una enzima que transfiere grupos metilo a los nucleótidos de citosina del ADN genómico. Esta proteína es la principal enzima responsable del mantenimiento de los patrones de metilación tras la replicación del ADN y muestra preferencia por el ADN hemimetilado. La metilación del ADN es un componente importante de la regulación génica epigenética en mamíferos. Se han encontrado patrones de metilación aberrantes en tumores humanos y se asocian con anomalías del desarrollo. La variación en este gen se ha asociado con ataxia cerebelosa, sordera, narcolepsia y neuropatía hereditaria sensorial de tipo IE. El empalme alternativo produce múltiples variantes de transcripción.
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