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Código SKU: E-AB-66264_60μL-ES
Anticuerpo policlonal CAND1, 60 μL
Este gen codifica un regulador esencial de las ligasas de ubiquitina Cullin-RING, que participan en la ubiquitinilación de proteínas degradadas por el sistema del proteasoma Ub. La proteína codificada se une a complejos proteicos de la caja cullin-RING no neddilados y actúa como inhibidor de la neddilación de cullin y del ensamblaje y la actividad de los complejos de ubiquitina ligasa de Skp1, cullin y caja F. En cultivos celulares de mamíferos, esta proteína se localiza predominantemente en el citoplasma. La inhibición de este gen en los preadipocitos provoca un bloqueo de la adipogénesis. El empalme alternativo da lugar a múltiples variantes de transcripción.
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