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Código SKU: E-AB-64807_200μL-ES
Anticuerpo policlonal CAMLG, 200 μL
El fármaco inmunosupresor ciclosporina A bloquea una señal dependiente de calcio del receptor de células T (TCR) que normalmente induce la activación de las células T. Al unirse a la ciclofilina B, la ciclosporina A se une e inactiva la calcineurina, el intermediario clave en la señalización. La proteína codificada por este gen funciona de forma similar a la ciclosporina A: se une a la ciclofilina B y actúa aguas abajo del TCR y aguas arriba de la calcineurina, provocando un influjo de calcio. Esta proteína integral de membrana parece ser un nuevo participante en la vía de transducción de señales de calcio, lo que implica a la ciclofilina B en la señalización de calcio, incluso en ausencia de ciclosporina.
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