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Código SKU: E-AB-53455_200μL-ES
Anticuerpo policlonal BRI3BP, 200 μL
BRI3BP (proteína de unión a BRI3), también conocida como BNAS1, HCCR-1, proteína de unión a I3 o proteína de unión al protooncogén KG19 del cáncer cervical 1, es una proteína de membrana multipaso de 251 aminoácidos. Aunque se expresa ampliamente, BRI3BP alcanza sus niveles máximos en cerebro, riñón e hígado, donde se localiza en el retículo endoplasmático (RE) y participa en la dinámica estructural del RE y la viabilidad mitocondrial. Con propiedades proapoptóticas y la capacidad de potenciar la apoptosis inducida por fármacos, se ha demostrado que la sobreexpresión de BRI3BP aumenta la liberación de caspasa-3 y citocromo c mitocondrial en células 293T de riñón embrionario humano tratadas con etopósido.
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