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Código SKU: E-AB-70258_200μL-ES
Anticuerpo policlonal BAG2, 200 μL
Las proteínas BAG compiten con Hip por la unión al dominio ATPasa Hsc70/Hsp70 y promueven la liberación del sustrato. Todas las proteínas BAG presentan un dominio BAG de aproximadamente 45 aminoácidos cerca del extremo C-terminal, pero difieren notablemente en sus regiones N-terminales. La proteína BAG2 prevista contiene 211 aminoácidos. Los dominios BAG de BAG1, BAG2 y BAG3 interactúan específicamente con el dominio ATPasa Hsc70 in vitro y en células de mamíferos. Las tres proteínas se unen con alta afinidad al dominio ATPasa de Hsc70 e inhiben su actividad chaperónica de forma reprimible por Hip.
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