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Código SKU: E-AB-16608_20μL-ES
Anticuerpo policlonal ATP2A1, 20 μL
Este gen codifica una de las Ca(2+)-ATPasas SERCA, bombas intracelulares ubicadas en el retículo sarcoplásmico o endoplasmático de las células musculares. Esta enzima cataliza la hidrólisis del ATP, junto con la translocación de calcio del citosol al lumen del retículo sarcoplásmico, y participa en la excitación y la contracción muscular. Las mutaciones en este gen causan algunas formas autosómicas recesivas de la enfermedad de Brody, caracterizadas por un deterioro creciente de la relajación muscular durante el ejercicio. El empalme alternativo da lugar a tres variantes de transcripción que codifican diferentes isoformas.
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