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Código SKU: E-AB-14751_60μL-ES
Anticuerpo policlonal ASCC1, 60 μL
Este gen codifica una subunidad del complejo cointegrador de la señal activadora 1 (ASC-1). El complejo ASC-1 es un coactivador transcripcional que desempeña un papel importante en la transactivación génica por múltiples factores de transcripción, como la proteína activadora 1 (AP-1), el factor nuclear kappa-B (NF-kB) y el factor de respuesta sérica (SRF). La proteína codificada contiene un motivo de unión a ARN de tipo KH N-terminal, necesario para la transactivación de AP-1 por el complejo ASC-1. Las mutaciones en este gen se asocian con el esófago de Barrett y el adenocarcinoma esofágico. Se han observado transcripciones de empalme alternativo que codifican múltiples isoformas para este gen.
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