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Código SKU: E-AB-10130_60μL-ES
Anticuerpo policlonal APEX1, 60 μL
Los sitios apurínicos/apirimidínicos (AP) se presentan con frecuencia en las moléculas de ADN por hidrólisis espontánea, por agentes que dañan el ADN o por ADN glicosilasas que eliminan bases anormales específicas. Los sitios AP son lesiones premutagénicas que pueden impedir la replicación normal del ADN, por lo que la célula cuenta con sistemas para identificar y reparar dichos sitios. Las endonucleasas AP de clase II escinden la cadena principal fosfodiéster en el extremo 5' del sitio AP. Este gen codifica la principal endonucleasa AP en las células humanas. Se han encontrado variantes de empalme para este gen; todas codifican la misma proteína.
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