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Código SKU: E-AB-F1351E_100T-ES
Anticuerpo APC anti-Foxp3 de ratón/rata [FJK-16s], 100 T
FOXP3 es un factor de transcripción de 47 kD, también conocido como proteína Forkhead box P3, Scurfin, JM2 o IPEX. Se propone que sea un gen regulador maestro y un marcador más específico de células T reguladoras que la mayoría de los marcadores de superficie celular (como CD4 y CD25). Expresión transducida de FOXP3 en CD4. + /CD25 - Se ha demostrado que las células inducen GITR, CD103 y CTLA4, e imparten un fenotipo de linfocito T regulador. FOXP3 está mutado en el síndrome de desregulación alérgica-autoinmunitaria ligado al cromosoma X (XLAAD o IPEX) en humanos y en ratones con caspa. Se ha demostrado que la sobreexpresión de FOXP3 provoca un estado inmunitario hipoactivo, lo que sugiere que este factor transcripcional es un regulador central de la actividad de los linfocitos T.
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Brands:Elabscience
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