Código SKU: E-AB-F1303E_100T-ES

Anticuerpo APC anti-CD193/CCR3 humano [5E8], 100 T

El CD193, también conocido como receptor de quimiocinas CC 3 (CCR3), CC CKR3, receptor tipo 2 de MIP1-alfa y receptor de eotaxina, pertenece a la familia de siete receptores transmembrana acoplados a proteína G. Se une con alta afinidad a las quimiocinas CC eotaxina, eotaxina-2 y eotaxina-3. También se ha descrito que el CCR3 se une con baja afinidad a RANTES, MCP-3 y MCP-4. El receptor CCR3 se expresa en eosinófilos, basófilos, mastocitos, fagocitos mononucleares, plaquetas, células progenitoras hematopoyéticas CD34+, linfocitos tipo Th2 y queratinocitos humanos. Se cree que el CCR3 desempeña un papel en enfermedades alérgicas como el asma bronquial y la rinitis alérgica. CCR3 es un correceptor del VIH-1 y del VIH-2, y se ha demostrado que la unión de la eotaxina con CCR3 inhibe la infección por VIH en algunos tipos de células.

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